• Analysis of the effect of the hepatic arterial infusion chemotherapy in combination with radiation for unresectable advanced hepatocellular carcinoma.
• Analysis of liver fibrosis with elastography.
• Analysis of the effects of partial splenic embolization (PSE) and splenectomy on decompensated cirrhosis.
• Analysis of therapeutic effect of radiofrequency ablation for hepatocellular carcinoma using real time virtual sonography (RVS) and contrast echo.
• Analyses of the serum micro RNAs in viral hepatitis.

• Animal experiments for the realization of the complete natural orifice transluminal endoscopic surgery (pure NOTES).
• Development of endoscope-related equipment by the Medical and engineering industry-academia-government collaboration project team (Kagawa NOTES project team) - a suturing device for flexible endoscope perfectly performing the full-thickness plication of gastrointestinal tract wall, a counter traction device to expand the operative field, etc.
• Joint development of biomedical engineering using micromachine technology (MEMS technology): Partnership with Kagawa University Faculty of Engineering microstructure device integration Research Center.
• Endoscopic vascular transection surgery for gastroesophageal varices.
• Relaxation incision surgery for postoperative gastrointestinal tract stenosis.
• Preventive effect of the steroid to the gastrointestinal tract stenosis.
• Bloc biopsy by tunneling method using endoscopic submucosal dissection for an upper gastrointestinal submucosal tumor.
• Studies on the effectiveness of post-ESD wound surface closure and the wound closure procedures itself.
• Basic research on the anti-tumor effect of metformin against gastrointestinal caner.
• Basic research on the anti-tumor effect of Galectin-9 against gastrointestinal caner.
• Micro RNA involvement in the digestive tract diseases.

• Diagnosis and treatment using the endoscopic retrograde cholangiopancreatography (ERCP); EST, lithotripsy, placement of metallic stent, etc.
• Treatment and diagnosis using the endoscopic ultrasound (EUS); EUS-FNA, EUS-PCD, EUS-BD, EUS-PD, necrosectomy on the infected pancreatic necrosis, IDUS, etc.
• Comprehensive analysis of the micro RNA of pancreatic cancer tissue obtained by EUS-FNA.
• Basic research on the anti-tumor effect of metformin against pancreatic cancer and biliary tract caner.
• The development of a new tumor marker of pancreatic cancer using serum micro RNA.

• Antitumor Effect of Regorafenib on MicroRNA Expression in Hepatocellular Carcinoma Cell Lines.
  Takuma K, et al. Int J Mol Sci. 23(3): 1667(2022)
• Long-Term Outcomes and Evaluation of Hepatocellular Carcinoma Recurrence after Hepatitis C Virus Eradication by Direct-Acting Antiviral Treatment: All Kagawa Liver Disease Group (AKLDG) Study.
  Tani J, et al. Cancers (Basel). 13(9): 2257, 2021
• Efficacy of Combined Therapy with Drug-Eluting Beads-Transcatheter Arterial Chemoembolization Followed by Conventional Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Multi-Center Study.
  Morishita A, et al. Cancers(Basel). 13(18): 4605(2021)

• Endoscopic ligation with O-ring closure for a large artificial defect after rectal endoscopic submucosal dissection.
  Tada N, et al. Dig Liver Dis. 54(1): 142-143(2022)
• Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies.
  Kozuka K, et al. J Clin Med. 10(17): 3796(2021)
• Flexible Magnifying Endoscopy with Narrow Band Imaging for Diagnosing Uterine Cervical Neoplasms: A Multicenter Prospective Study.
  Kobara H, et al. J Clin Med. 10(20): 4753(2021)

• Telomerase Reverse Transcriptase Promoter Mutations in Human Hepatobiliary, Pancreatic and Gastrointestinal Cancer Cell Lines.
  Hirata M, et al. In Vivo. 36(1): 94-102(2022)
• Correction: Endoscopic direct visualization of gallbladder polypoid lesion using peroral digital single-operator cholangioscopy.
  Kamada H, et al. Endoscopy. 53(7): C8(2021)
• MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells.
  Yamana Y, et al. JCRT. 1-8(2021)

• A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy.
  Nonaka W, et al. Mol Med Rep. 25(3): 88(2022)
• Ascending spinal tract formation in chick embryo originating from different spinal regions.
  Kokudo Y, et al. Brain Res. 1768: 147595 (2021)

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