Molecular Neurobiology
Staff
Prof. YAMAMOTO
Current Research Projects
- Pathophysiology of schizophrenia and autism spectrum disorders focusing on regulation of the balance between excitation and inhibition within neural circuitry.
- Pathophysiology of ischemic stroke focusing on elucidation of mechanism protecting the brain from acute insults.
- Analysis of APP metabolism in a physiological condition for understanding the etiology of sporadic Alzheimer's disease.
Representative Publications
- Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Takahashi N, et al. Proc. Natl. Acad. Sci. USA. 118, e2018850118 (2021).
- Amyloidogenic processing of amyloid β protein precursor (APP) Is enhanced in the brains of Alcadein α-deficient mice.
Gotoh N, et al. J. Biol. Chem. 295, 9650-9662 (2020).
- Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism linked excitatory synaptic supressor MDGA2.
Steven AC, et al. Neuron 91, 1052-1068 (2016).
Contact Information
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